格兰酶B PET/CT成像评估了胃癌免疫治疗的早期反应
Qiufang Liu1,2,3,4, Xiaoping Xu1,2,3,4, Ziyi Yang1,2,3,4
1Department of Nuclear Medicine, Shanghai Cancer Center, Fudan University, Shanghai, China.
概括
这项研究表明[68Ga]Ga-NOTA-GSI PET/CT可以预测胃癌中免疫治疗的早期反应. 瘤和淋巴结中的更高的标记物吸收表明治疗反应更好.
科学领域:
- 核医学就是核医学.
- 在瘤学瘤学.
- 放射化学 放射化学是指辐射化学.
背景情况:
- 预测患者对恶性瘤中免疫检查点抑制剂 (ICI) 的反应是非常重要的,因为反应有限.
- 在胃癌治疗过程的早期监测治疗疗效仍然是一个未满足的临床需求.
研究的目的:
- 开发和评估一种新型的PET/CT探头[68Ga]Ga-NOTA-GSI,其向的是B.大酶.
- 调查[68Ga]Ga-NOTA-GSI PET/CT对于早期预测胃癌联合免疫疗法反应的实用性.
主要方法:
- 72名患有III-IV期胃癌的患者在2-3轮免疫治疗后接受了[68Ga]Ga-NOTA-GSI PET/CT.
- 测量了包括SUVmax在内的定量PET参数,瘤和淋巴结的目标与背景比率 (TLR,TBR).
- 使用RECIST 1.1评估治疗反应,并对响应者和非响应者进行统计比较.
主要成果:
- 与非响应者相比,响应者在原发性瘤和转移性淋巴结中显示出显著更高的SUVmax和TBR值 (P <0.05).
- 接收器操作特征 (ROC) 曲线分析显示,SUVmax-t (AUC 0.886) 和TBR瘤 (AUC 0.866) 的诊断效果很好.
- 确定TBR瘤是治疗反应的独立预测因子 (P = 0.03).
结论:
- [68Ga]Ga-NOTA-GSI PET/CT是一种有前途的成像工具,用于预测胃癌患者对联合免疫治疗的早期反应.
- 探针允许对治疗效果进行非侵入性监测,有助于治疗分层和管理.
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