莱博雷克桑特对睡眠失眠患者的有效性和安全性 - 一项前性研究
Yoshikazu Togo1, Yohei Kaizuka1, Seiji Nagasawa1
1Department of Urology, Kawanishi City Medical Center, Hyogo, Japan.
Lower urinary tract symptoms
|October 10, 2024
概括
伦博雷克桑特显著改善了睡眠质量,并减少了失眠和夜患者的夜发作. 治疗还增加了夜间空置体积,延长了不间断的睡眠时间,主要副作用是轻微的嗜睡.
科学领域:
- 睡眠医学 睡眠医学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 夜,定义为两个或两个以上的夜间空虚,是一种与抑郁症,跌倒和死亡率相关的临床问题.
- 现有的治疗失眠与夜症往往有局限性.
研究的目的:
- 评估Lemborexant在患有失眠和夜尿症的患者中的疗效和安全性.
主要方法:
- 32名患有失眠症 (雅典失眠量表得分≥6) 和夜尿症 (≥2次/晚) 的成年患者每天接受5毫克的莱博雷克桑特,持续4周.
- 评估结果包括AIS总得分,夜频率,夜间空置体积,不间断睡眠的持续时间和夜生活质量 (N-QOL) 评分.
主要成果:
- 伦博雷克桑特显著减少了从3.4到2.3的平均夜发作 (p < 0.001),并从11.4到7.8 (p < 0.01) 的平均AIS总得分得到改善.
- 夜间排空体积显著增加,从182.5升至225.3毫升 (p < 0.001),不间断睡眠时间从105.3升至174.8分钟 (p < 0.001).
- 平均总N-QOL得分从49.6%显著改善到64.8% (p < 0.001),在三名患者中报告了轻度昏昏欲睡.
结论:
- 伦博雷克桑特 (Lemborexant) 显示出作为患有并发性失眠和夜尿症的个人有效和安全的治疗选择的潜力.
- 该药物改善了关键的夜症状和睡眠质量,这表明它对患者的生活质量产生了积极影响.
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