根据BMI状态,青春期前儿童患有过度饮食障碍的功能性连接性表型不同
Trevor Steward1, Kay Jann2, Stuart B Murray3
1Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, Victoria, Australia.
Obesity (Silver Spring, Md.)
|October 10, 2024
概括
儿童的暴饮暴食障碍 (BED) 显示了大脑连接的改变,特别是在奖励和默认模式网络之间. 这些变化与BED本身有关,而不仅仅是体重状况,影响情绪调节.
科学领域:
- 神经科学是一个神经科学.
- 儿童精神病学 儿童精神病学
- 脑部成像 脑部成像
背景情况:
- 儿科暴饮暴食障碍 (BED) 的神经生物学机制尚不清楚.
- 变化可能源于BED,肥胖或两者.
- 了解这些机制对于早期干预至关重要.
研究的目的:
- 研究有或没有BED的儿童在抑制控制和奖励网络中的功能连接 (FC).
- 在BED组内根据身体质量指数 (BMI) 区分FC模式.
- 为了澄清青春期前BED的特定神经生物学基础.
主要方法:
- 休息状态功能连接 (FC) 分析使用前额叶皮层的种子区域,前带皮层,后带皮层,轨道前皮层,内核和杏仁体.
- 种子-素分析与患有BED (高与低BMI) 和对照儿童的FC进行了比较.
- 利用了青少年大脑认知发展 (ABCD) 研究的数据.
主要成果:
- 患有BED的儿童表现出奖励网络和默认模式网络区域之间的连接性降低,独立于BMI.
- 在BED中观察到前-桃体电路的低连接性,与情绪调节受损有关.
- 这些FC变化似乎特定于BED而不是肥胖.
结论:
- 奖励和默认模式网络之间的功能连接差异与儿童的BED有关.
- 这些发现表明BED,而不是体重状况,是观察到的FC变化的主要驱动因素.
- 结果突出了理解和治疗儿科BED的潜在目标.
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