药物使用和多药学的新联系与肠道微生物群的组成和功能潜力在大量人群中
Anna Larsson1, Ulrika Ericson1, Daniel Jönsson1,2,3
1Department of Clinical Sciences in Malmö, Lund University Diabetes Center, Lund University, Malmö, Sweden.
Scientific reports
|October 10, 2024
概括
常见的非抗生素药物显著改变肠道微生物群的组成和功能. 这项大型瑞典研究发现了特定药物,多种药物和肠道微生物物种和代谢途径之间的许多新联系.
科学领域:
- 微生物组研究的研究.
- 药理学 药理学是指药理学的学科.
- 人类健康 人类健康 人类健康
背景情况:
- 药物可以影响肠道微生物群.
- 了解这些影响对于整体健康至关重要.
- 非抗生素药物被广泛使用,需要对其微生物影响进行研究.
研究的目的:
- 调查常见的非抗生素药物与肠道微生物群的组成和功能之间的关联.
- 分析来自瑞典大型队列的数据,使用自我报告和注册数据.
- 为了确定特定的微生物物种和代谢途径受到药物使用和多药物的影响.
主要方法:
- 分析了2223个人的肠道基因组数据.
- 67种药物/多种药物和881种微生物/103种代谢模块之间的关联分析.
- 利用自我报告和处方注册表数据作为药物信息.
主要成果:
- 在26种药物和40种物种,以及4种药物和5种代谢模块之间确定了97个显著的关联.
- 复制已知的关联,例如,与口服物种的质子抑制剂 (PPI) 和与埃舍里希亚菌的甲型胺.
- 发现抗抑郁药,β-阻断剂,NSAID和通道阻断剂与特定肠道微生物的新兴关联.
结论:
- 证实了药物使用/多药和肠道微生物群之间的现有联系,并揭示了许多新的联系.
- 多种药物与特定细菌 (如Enterococcus faecalis和Escherichia coli) 以及代谢模块有积极的关联.
- 需要进一步的研究来验证这些新发现的药物-微生物群相互作用.
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