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循环炎症蛋白对肠道微生物群和FD之间的关系的调解作用:双向的门德尔随机化研究

Li Li¹, Minhan Fu¹, Feiyi Chen¹

¹Department of Acupuncture and Rehabilitation, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China.

Scientific reports

|October 10, 2024

概括

这项研究调查了功能性消化不良 (FD) 中肠道微生物群 (GM) 和循环炎症蛋白 (CIP) 之间的因果关系. 发现特定的转基因和CIP有因果关系影响FD风险,提供新的诊断和治疗点.

科学领域:

胃肠病学胃肠病学
免疫学免疫学免疫学
微生物组研究微生物组研究

背景情况:

功能性消化不良 (FD) 受肠道微生物群 (GM) 和循环炎症蛋白 (CIP) 的影响.
转基因,CIP和FD之间的因果关系在很大程度上仍未得到调查.
了解这些联系对于开发有效的FD治疗至关重要.

研究的目的:

研究遗传预测肠道微生物群和循环炎症蛋白与功能性消化不良之间的因果关系.
确定在FD病变发生过程中起因作用的特定的转基因特征和CIP.
探索CIP在GM-FD轴上的潜在调解角色.

主要方法:

采用两样本的孟德尔随机化 (TSMR),使用全基因组关联研究 (GWAS) 数据.
采用反变量加权 (IVW) 作为主要分析,并补充加权中位数,加权模式,简单模式和MR-Egger方法.
通过使用Cochrane Q测试,MR-Egger拦截和MR-PRESSO全球测试来评估异质性和性.

主要成果:

确定了12种转基因种类和5种蛋白质对功能性消化不良的因果影响.
发现9个转基因属与FD风险降低相关,3个转基因属与FD风险增加相关.
揭示了IL-12,IL-10,CXCL10,CXCL9和VEGFA与FD之间的显著相关性,CXCL9和VEGFA调解了GM-FD关联.

结论:

在功能性消化不良的发病过程中,特定的肠道微生物群和循环的炎症蛋白之间建立了因果关系.
根据已识别的转基因和CIP,突出了FD的潜在诊断生物标志物和治疗目标.
提供了对肠道微生物组,炎症和FD之间的复杂相互作用的新见解.

关键词:

循环中的炎症蛋白质.功能性消化不良症功能性消化不良症我们的肠道微生物群.调解分析调解分析门德尔的随机化

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