产前母亲糖尿病,并发症和神经发育障碍的风险在前两年
Samson Nivins1, Gerald F Giesbrecht2, Lianne Tomfohr-Madsen3
1Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Pediatric research
|October 10, 2024
概括
母亲糖尿病与超重,肥胖或妊娠高血压疾病相结合,会增加婴儿神经发育延迟的风险. 这些联合的产前暴露显著影响后代的发育,远远超过单独的糖尿病.
科学领域:
- 周围生理学 周围生理学
- 发育儿科 发育儿科
- 产科 产科 产科 产科 产科
背景情况:
- 孕产妇糖尿病是一种已知的神经发育迟缓后代的风险因素.
- 肥胖和高血压等并发症通常伴随着母亲糖尿病.
- 孕产妇糖尿病和伴随性疾病对神经发育结果的综合影响需要进一步研究.
研究的目的:
- 调查母亲糖尿病和伴随疾病与神经发育迟缓风险在12个月和24个月的儿童之间的独立和联合关联.
- 为了澄清产前暴露对婴儿神经发育的影响.
主要方法:
- 潜在的纵向队列研究 (COVID-19大流行期间的怀孕).
- 在12个月和24个月使用年龄和阶段问卷进行神经发育查.
- 对特定领域的发展进行评估.
主要成果:
- 单独母婴糖尿病并没有与12个月或24个月的神经发育风险有关.
- 母亲糖尿病与怀孕前超重或肥胖相结合,增加了24个月个人-社会和沟通延迟的风险.
- 孕妇糖尿病与妊娠高血压障碍 (HDP) 增加了12个月的精细运动技能延迟.
- 孕前孕产妇的肥胖和HDP独立地增加了24个月的沟通,精细运动和个人社会延迟的风险.
结论:
- 与伴随性疾病结合的孕产妇糖尿病显著增加了婴儿神经发育迟缓的风险,而不是单个暴露.
- 产前暴露对后代的神经发育有着持续的影响.
- 确定可修改的产前风险因素对于有针对性的干预和改善儿童健康结果至关重要.
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