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Updated: Jun 10, 2025

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关于QSP模型标准化发布协议的建议

Jared Weddell1, Abhishek Gulati2, Akihiro Yamada3

  • 1Early Development, New Technology, Astellas Pharma Inc, Northbrook, IL, USA.

Journal of pharmacokinetics and pharmacodynamics
|October 10, 2024
PubMed
概括

开发定量系统药理 (QSP) 模型是具有挑战性的,因为缺乏标准的出版实践,阻碍可重复性. 本研究调查了QSP模型可重现性问题,并提出了标准实践和出版协议,以改善知识保存.

关键词:
在中期,中期.机械模型建模 机械模型质量服务提供商QSP可复制性 可复制性

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Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
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