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在患有急性骨髓炎的儿童中,甲素耐药黄金葡萄球菌感染的预测因素

Kang Wang¹, Chen Wang², Hua Zhu²

¹Department of Orthopedics, Children's Hospital of Hebei Province, No. 133 Jianhua South Street, Shijiazhuang City, Hebei Province, China. wangkang5@126.com.

Italian journal of pediatrics

|October 10, 2024

概括

患有急性骨髓炎 (AO) 的儿童患有甲素耐药金黄色葡萄球菌 (MRSA) 感染与较高的C反应蛋白 (CRP) 和白细胞 (WBC) 数量有关. 在儿科AO病例中早期识别MRSA可以通过特定的临床和实验室标记物得到帮助.

科学领域:

儿童传染病儿童传染病
临床微生物学临床微生物学
整形外科手术整形外科手术

背景情况:

急性骨髓炎 (AO) 是一种可能影响儿童的骨感染.
甲素耐药黄金葡萄球菌 (MRSA) 是医疗保健相关感染的常见原因.
在儿科AO中早期发现MRSA对于有效治疗至关重要.

研究的目的:

在患有AO的儿童中确定MRSA感染的危险因素.
在患有AO的MRSA感染儿童中描述实验室发现.
改善儿童AO中MRSA的早期有针对性的治疗干预措施.

主要方法:

对123名患有AO的儿童进行了回顾性分析.
在入院时测量WBC,CRP,ESR和血小板计数.
分类为非MRSA (n=73) 和MRSA (n=50) 组.

主要成果:

MRSA 组的平均年龄更高,并且在入院时CRP水平明显升高.
在MRSA组中,辅助性关节炎的发病率较低.
在经验性治疗三天后,MRSA组中WBC和CRP水平持续升高.

结论:

住院时的CRP水平> 73.23μg/mL可能表明儿科AO的MRSA感染.
特定标记 (WBC>10.95×10^9/L,CRP>49.56μg/mL,年龄>3.5年,没有性关节炎) 表明治疗3天后MRSA风险增加.

关键词:

潘顿瓦伦丁的白细胞杀伤剂.急性血源性骨髓炎是一种严重的疾病.儿科儿科儿科败血性关节炎是什么意思

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