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在ALS/FTD基因VCP中发生的致病突变通过调节透性过渡孔诱导线粒体超能代谢

Silke Vanderhaeghe1,2,3, Jovan Prerad3, Arun Kumar Tharkeshwar4,5

  • 1Laboratory of Neurobiology, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.

Acta neuropathologica communications
|October 10, 2024
PubMed
概括

与ALS和FTD相关的VCP基因突变破坏了线粒体功能,导致线粒体扩大和能量代谢改变. 这表明VCP对线粒体健康至关重要,并可能解释疾病的进展.

关键词:
肌缩性侧面硬化症 (AMLS) 是一种疾病.在前性痴呆症.线粒体中的线粒体.线粒体功能障碍 线粒体功能障碍线粒体的透性过渡孔.这是一个VCPVCP.

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