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简单的同时分析各种心血管药物混合与芬卡明:比较环保评估

Sara S Mourad¹, Magda A Barary¹, Amira F El-Yazbi²

¹Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Alexandria University, 1 El Khartoum Square, Alexandria, 21521, Egypt.

|October 10, 2024

概括

开发了使用小粒电动动色谱 (MEKC) 和高性能液体色谱 (HPLC) 的环保分析方法,用于同时确定心血管药物和胺. 这些经过验证的方法具有成本效益,灵敏,适合用于制药分析和生物矩阵.

科学领域:

分析化学分析化学
药品分析药品分析
绿色化学绿色化学

背景情况:

同时确定心血管药物和营养保健品对于制药分析至关重要.
现有的方法可能与绿色化学原则不一致,需要可持续的替代方法.
开发环保分析技术对于减少药物分析对环境的影响至关重要.

研究的目的:

开发和验证两种环保的分析方法,用于同时确定八种心血管药物和一种营养药物.
应用微粒电动力染色学 (MEKC) 和高性能液体染色学 (HPLC) 进行可持续的药物分析.
评估开发方法的绿色,白色和蓝色指标.

主要方法:

状电动力学染色学 (MEKC) 使用化毛细血管与酸盐缓冲剂,酸硫酸和酸.
高性能液体染色学 (HPLC) 使用ZORBAX Extend-C18柱,其中含有酸盐缓冲和甲醇的梯度移动相.
验证两种方法的线性,检测极限 (LOD) 和量化极限 (LOQ).

主要成果:

两种MEKC和HPLC方法都表现出极好的线性 (r ≥ 0.9996) 与低的LOD和LOQ值.
这些方法已成功地用于确定联合使用的单,二元和三元剂型.
在大鼠血样本中证实了适用性,在不同的矩阵中展示了多功能性.

结论:

开发的MEKC和HPLC方法是高效的,敏感的,可重复的,具有成本效益和节省时间的.
这些绿色分析方法符合可持续性原则,减少有机溶剂的使用和浪费.
这些方法适用于常规药品分析和复杂药物配方的质量控制.

关键词:

蓝色是一种蓝色.心血管疾病的药物.绿色是绿色的绿色是绿色的在HPLC中使用HPLC.在MEKC中,MEKC是MEKC.文卡明 (Vincamine) 是一种这是白色的白色.

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