氧化的特罗格基宏循环阵列:在水中前所未有的反选择性识别
Xiaotong Liang1, Ting Zhao2, Yanling Shen1
1Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, 610064, China.
Angewandte Chemie (International ed. in English)
|October 11, 2024
概括
合成受体与水中的反抗选择性作斗争. 这项研究介绍了氧化特罗格尔.
科学领域:
- 超分子化学 超分子化学
- 有机化学 有机化学
- 分析化学 分析化学
背景情况:
- 在合成受体中,特别是在水性环境中,达到高的反抗选择性是一个持续的挑战.
- 自然生物系统表现出有效的抗选择性识别,作为合成方法的基准.
研究的目的:
- 开发一种新型的合成受体类别,具有增强的水溶性和酶选择性能力.
- 调查含有特罗格基 (TB) 的宏循环及其氧化衍生物在水中的性识别的潜力.
主要方法:
- 易于合成含有特罗格基 (TB) 的宏环 (TBn) 具有刚性框架.
- 氧化 enantiopure TBn 转化为氧化物 (TBnNO),使其具有水溶性.
- 对在水溶液中对各种奇拉性客体进行TBnNO的对抗选择性识别的评估.
主要成果:
- 由于极性N-O键,TBnNO表现出极好的水溶性,克服了传统方法的pH限制.
- 在水中对各种性客体进行了显著的酶选择性识别,其酶选择性高达41.0.0.
- 这种识别机制归因于水性相互作用和硬体效应在刚性性腔内的结合.
结论:
- 氧化宏循环 (TBnNO) 是水中超分子应用的一个有前途的新平台.
- 开发的TBnNO受体为在水性介质中进行酶选择性识别提供了一个变革性的工具.
- 这项工作推动了合成受体的设计,以适应水等具有挑战性的环境.
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