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Updated: Jun 10, 2025

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在7-基托胆固醇诱导的人类大动脉内皮功能障碍中的miR-134-5p的作用

Kind-Leng Tong1, Ahmad Syadi Mahmood Zuhdi2, Pooi-Fong Wong1

  • 1Department of Pharmacology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.

EXCLI journal
|October 11, 2024
PubMed
概括

微RNA-134-5p与内皮功能障碍有关,这是动脉样硬化的前体. 针对这种microRNA可能为急性冠状动脉综合征 (ACS) 提供新的治疗途径.

关键词:
7-基托胆固醇的使用内皮质功能障碍 在内皮质功能障碍人类大动脉内皮细胞在 miR-134-5p 中使用.

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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