一个反复出现的主题:一种罕见的Pembrolizumab诱导的急性间歇性炎病例
Jonathan London1, Sabrina Bulancea1, Inaas Shirazi1
1Department of Internal Medicine, Long Island Community Hospital, USA.
Journal of community hospital internal medicine perspectives
|October 11, 2024
概括
布罗利祖马布是癌症的免疫疗法,很少会导致急性间歇性炎 (AIN). 这一案例突显了在接受布罗利祖马布治疗的转移性状细胞癌患者中出现的复发性AIN.
科学领域:
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
背景情况:
- 布罗利祖马布是一种针对PD-1通路的免疫检查点抑制剂,广泛用于各种癌症.
- 潘布罗利祖马布的副作用很常见,急性间歇性炎 (AIN) 是一种罕见但严重的并发症.
- 免疫相关的不良事件 (irAEs) 可以影响多个器官系统.
研究的目的:
- 在接受 pembrolizumab 治疗的患者中报告复发性急性间歇性炎 (AIN) 的病例.
- 强调识别和管理AIN作为PD-1抑制剂的irAE的重要性.
- 为了解与癌症免疫疗法相关的罕见不良事件作出贡献.
主要方法:
- 一个79岁的男性患有转移性逆皮质状细胞癌的病例报告.
- 对患者的病史和 pembrolizumab 治疗过程的审查.
- 诊断和治疗复发性急性间歇性炎.
主要成果:
- 患者在为转移性平细胞癌接受 pembrolizumab 治疗期间出现了复发性急性间歇性炎.
- 该案例说明了与PD-1抑制剂治疗相关的罕见但显著的不良事件.
- 对于患有脏并发症的患者来说,及时识别和管理至关重要.
结论:
- 复发的急性间歇性炎是 pembrolizumab 治疗的潜在副作用之一.
- 在接受PD-1抑制剂的患者中,临床医生应保持对AIN的高度怀疑指数,特别是那些有病史的患者.
- 这一案例强调了在接受免疫治疗的患者中对功能进行警监测的必要性.
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