基于人口的丹麦队列中心血管事件的发生率与亚托皮性皮肤炎
Alexander Egeberg1,2, Andreas Wollenberg3,4, Thomas Bieber5
1Bispebjerg University Hospital, University of Copenhagen, Copenhagen, Denmark.
The journal of allergy and clinical immunology. Global
|October 11, 2024
概括
心血管疾病的风险在阿托皮性皮肤炎 (AD) 患者和一般人群中是相似的. 然而,特定的风险因素增加了AD患者静脉血栓栓塞 (VTE),恶性瘤和主要心血管不良事件 (MACE) 的可能性,需要监测.
科学领域:
- 皮肤病学和心血管流行病学
- 临床研究和公共卫生
背景情况:
- 阿托皮炎 (AD) 与心血管疾病 (CVD) 风险之间的关联仍然不清楚.
- 了解AD中的心血管疾病风险对于全面的患者护理至关重要.
研究的目的:
- 为了确定静脉血栓塞栓症 (VTE) 的发病率 (IR) 在皮炎 (AD) 患者.
- 评估动脉样硬化心血管疾病 (ASCVD) 风险因素,恶性瘤,主要心血管不良事件 (MACE) 和AD和类风湿性关节炎 (RA) 队列中的VTE发病率.
主要方法:
- 基于人口的队列研究,使用丹麦国家患者登记数据 (2000-2018).
- 年龄和性别匹配分析比较AD患者 (n=17,341) 与健康对照 (n=173,410).
- 嵌套队列分析包括RA患者,并评估ASCVD风险因素,如年龄,吸烟和先前的心血管事件.
主要成果:
- 在AD患者和对照人群中,整体VTE发病率在AD患者和对照人群之间是可比的.
- 与对照组相比,65岁及以上的AD患者的VTE发病率更高.
- 在RA患者中,ASCVD风险因素比AD患者更为普遍;恶性瘤和MACE显示了特定ASCVD风险因素的IR增加.
结论:
- 心血管事件发生率在阿尔茨海默病患者和普通人群中相似.
- 存在特定的ASCVD风险因素会增加AD患者的VTE,恶性瘤和MACE的风险.
- 建议对患有AD和同时存在的ASCVD风险因素的人进行密切的患者监测.
关键词:
动脉样硬化心血管疾病.丹麦 丹麦 丹麦 丹麦 是一个国家.简氏酶抑制剂 简氏酶抑制剂亚托邦性皮肤炎的发生.深静脉血栓形成的原因是深静脉血栓形成.主要的心血管不良事件.恶性瘤是一种恶性瘤.肺栓塞 肺栓塞是一种肺栓塞.类风湿性关节炎 类风湿性关节炎静脉血栓塞栓症是一种静脉血栓塞栓.更多相关视频
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