在放射治疗期间处理直肠运动:我们如何预测它?
Julien Pierrard1,2, Sofie Heylen2, Ad Vandermeulen2
1UCLouvain, Institut de Recherche Experimentale et Clinique (IREC), Center of Molecular Imaging, Radiotherapy and Oncology (MIRO), Brussels, Belgium.
Technical innovations & patient support in radiation oncology
|October 11, 2024
概括
放射治疗期间的直肠运动受到疗程持续时间,瘤的存在和距离直肠结节的距离的影响. 量身定制的放射治疗,包括适应技术,对于管理前列腺癌和直肠癌患者的这些变异至关重要.
科学领域:
- 辐射瘤学 辐射瘤学
- 医疗成像医学成像
- 解剖运动分析 解剖运动分析
背景情况:
- 直肠运动显著影响盆腔放射治疗的准确性.
- 了解影响直肠运动的因素对于优化治疗提供至关重要.
研究的目的:
- 为了研究放射治疗疗程持续时间,直肠内瘤的存在,以及距离直肠结 (ARJd) 的距离对直肠运动的影响.
- 为了比较患有直肠癌和没有直肠癌的患者接受盆腔放射治疗之间的直肠运动.
主要方法:
- 对20名患者 (10例直肠癌,10例前列腺癌) 的形光束计算机断层扫描 (CBCT) 的分析.
- 使用豪斯多夫距离95%和平均距离达成一致的方法量化内部和间断直肠运动.
- 线性混合模型评估了与会议持续时间,瘤存在和ARJd相关的运动.
主要成果:
- 在增加放射治疗时间和直肠运动之间发现了显著的相关性 (p < 0.05).
- 与直肠癌患者相比,前列腺癌患者的直肠运动明显高 (p < 0.01).
- 对于所有评估的结构来说,直肠运动随着距离直肠结的距离越大 (p < 0.001),显著增加.
结论:
- 放射治疗疗程的持续时间,缺少直肠瘤和ARJd是与增加直肠内和间断直肠运动相关的关键因素.
- 量身定制的放射治疗方法,如在线适应性放射治疗,是必要的,以管理直肠运动变化.
- 建议在前列腺癌患者和直肠癌患者之间对直肠运动进行差异化管理.
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