利多卡因治疗前治疗苏奇尼尔胆诱导的术后肌痛和相关因素:长度研究
Fassil Mihretu1,2, Telake Azale3, Foziya Mohammed4
1Wollo University, College of Medicine and Health Sciences, Department of Anesthesia, Dessie, Ethiopia.
Surgery open science
|October 11, 2024
概括
利多卡因预治疗显著降低了由苏奇尼尔胆引起的术后肌痛. 这项研究还发现,多式止痛和非类固醇抗炎药物可以帮助管理这种常见的外科副作用.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 手术患者护理手术患者护理
背景情况:
- 手术后肌痛是手术后常见的并发症,主要与使用肌肉松剂苏奇尼尔胆有关.
- 目前存在的预防策略对于苏奇尼尔胆诱导的肌痛缺乏明确的证据,突出需要进一步的研究.
研究的目的:
- 调查利多卡因预治疗对降低基尼尔胆诱导的术后肌痛的疗效.
- 确定其他可能影响术后肌痛发生率的因素.
主要方法:
- 进行了一项前性纵向队列研究,涉及208名成年外科患者.
- 患者被分为利多卡因预处理 (暴露) 和未预处理 (未暴露) 组.
- 术后肌痛使用重复调查进行评估,并使用科克兰的Q测试和通用估计方程 (GEE) 分析数据.
主要成果:
- 利多卡因预治疗显示,术后肌痛显著减少 (调整后几率比率[AOR] = 0.33,95% CI = [0.17,0.66]).
- 肌痛发生率在利多卡因组 (22-29.8%) 与未暴露组 (34-42.7%) 相比,在手术后12,24和48小时,肌痛发生率较低.
- 多模式止痛 (AOR = 0.32),NSAIDs (AOR = 0.47),术后不运动 (AOR = 0.61) 和男性性别 (AOR = 0.48) 也与肌痛的减少有关.
结论:
- 利多卡因预治疗是一种有效的策略,可显著降低基尼尔胆诱导的术后肌痛.
- 在外科手术期间使用多式止痛药或非类固醇抗炎药 (NSAIDs) 也可以减轻术后肌痛.
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