一项系统性审查评估了动脉样硬化和腰椎退行性磁盘疾病之间的关联
Wensen Li1, Niek Djuric1, Carmen L A Vleggeert-Lankamp1,2
1Neurosurgical Center Holland, Leiden University Medical Centre & Haaglanden MC & Haga Teaching Hospital, Leiden, the Netherlands.
Brain & spine
|October 11, 2024
概括
血管健康,包括腹腔大动脉化和脂质概况,与腰椎退化和相关的腰部疼痛有关. 血液供应不良可能导致脊柱退化和症状,需要进一步调查.
科学领域:
- 整形外科 整形外科 整形外科
- 心脏病学 心脏病学
- 放射学 放射学是一门学科.
背景情况:
- 腰部疼痛 (LBP) 和 sciatica 经常与腰椎间盘 (LDH) 和椎间盘退化 (DD) 相关.
- 新兴研究表明,诸如腹腔大动脉化 (AAC) 等血管健康标志物和系统性脂质样本与脊柱状况之间存在联系.
研究的目的:
- 为了调查AAC,脂质样本,腰部模态变化 (MC),DD/LDH,以及LBP或坐骨折的发病率之间的联系.
- 综合目前关于血管健康和腰椎病理之间的关系的证据.
主要方法:
- 在多个数据库中进行了全面的文献搜索,截至2023年8月.
- 研究是根据预先定义的标准进行选择的,并使用适应的Cochrane检查清单对偏见进行评估.
- 包括的研究重点是AAC或脂质状况与DD/LDH和/或LBP/Sciatica之间的关系.
主要成果:
- 分析包括了27项研究.
- 四项研究表明,AAC/腰椎动脉狭窄和LBP/脑脊之间存在正相关性.
- 七项研究发现AAC和DD/LDH之间存在积极关联,而八项研究则将脂质状况与DD/LDH联系起来.
结论:
- 有证据支持受损血液供应在磁盘退化,炎症和LBP中的作用.
- 局部血管因素和全身脂质样本似乎都影响腰椎退化.
- 需要进一步的研究来阐明这些关系,并为预防和治疗策略提供信息.
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