相关实验视频

Updated: Jun 10, 2025

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt

Published on: May 7, 2015

对0.9%正常盐水与乙酸甘酸盐基平衡溶液的比较评价,对捐赠肝切除术患者的酸状态和术后肝功能进行比较

Sonam Satija^1,2, Shashank Pandey², Neetu Jain²

¹Department of Anesthesiology, Institute of Liver and Biliary Sciences, Delhi, IND.

|October 11, 2024

概括

与正常盐水相比,PlasmaLyte A®在肝脏捐赠手术期间更好地保持酸平衡. 这种平衡的溶液减少了对代谢性酸化治疗的需要,显示出更安全的流体管理的潜力.

科学领域:

麻醉学和外科手术期间的医学.
移植手术移植手术
密集护理医学密集护理医学

背景情况:

活体供体肝移植需要仔细管理生理参数,包括酸平衡.
心血管不稳定和电解质不平衡是已知的供体肝切除过程中的并发症.
保持最佳的酸状态对于患者安全和手术结果至关重要.

研究的目的:

为了比较PlasmaLyte A®与0.9%的正常盐溶液在活体供体肝移植期间保持酸平衡的疗效.
评估这些液体溶液对术后肝功能和代谢稳定性的影响.
评估每个流体组的酸纠正干预措施的需要.

主要方法:

一项前性观察性研究,涉及40名健康的成年肝脏捐赠者,交替分配接受0.9%盐水或PlasmaLyte A®.
监测酸状态 (pH,HCO3),血液动力学参数和多次间隔的肝功能测试.
使用IBM SPSS的统计分析,显著程度为p <0.05.

主要成果:

与0.9%盐水组 (组1) 相比,PlasmaLyte A®组 (组2) 显示出明显更好地保持了酸平衡,pH和HCO3水平更高.
第1组的HCO3水平显著下降,表明发生了代谢性酸性疾病的趋势,需要在9名患者中补充二碳酸盐.
第二组需要更少的二碳酸盐补充剂 (三名患者),并显示了改善代谢稳定性和术后肝功能的趋势.
两组之间血液动力学参数或尿液输出没有显著差异.

结论:

在活体供体肝移植中,PlasmaLyte A®提供优越的酸平衡维护,与0.9%的正常盐水相比.
均衡的晶体溶液可能会导致降低代谢酸和减少对干预措施的需求,如二碳酸.
对于这种手术患者群体来说,PlasmaLyte A® 具有潜在的更安全,更有效的流体管理策略,尽管在本研究中,肝功能结果相似.

关键词:

酸平衡是指酸的平衡.肝切除术 (hepatatectomy) 是一种切除肝脏的方法.静脉注射液体疗法是一种静脉注射液体疗法.活体捐赠者的肝脏移植移植术后肝功能术后肝功能

更多相关视频

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

相关概念视频

Solution Composition During Acid/Base Titrations

Solution Composition During Acid/Base Titrations

The titration of a weak acid with a strong base results in the formation of water and the conjugate base of the acid. For instance, titrating acetic acid with sodium hydroxide leads to the formation of water and sodium acetate. A solution of acetic acid and sodium acetate constitutes a buffer whose relative concentration at different stages of the titration is indicated by the α values, which represent percentages of the weak acid and its conjugate base.
The α0 and α1 values...

Diagnosing Acidosis and Alkalosis

Diagnosing Acidosis and Alkalosis

Diagnosing acid-base imbalances involves systematically analyzing arterial blood samples, focusing on three key measurements: pH, bicarbonate (HCO3−) concentration, and carbon dioxide partial pressure (PCO2). This analysis follows a four-step process that helps identify the imbalance's underlying cause and nature.
First, the pH level is assessed to determine whether the blood pH is normal (7.35–7.45), low (acidosis), or high (alkalosis).
Next, the PCO2 and...