状细胞贫血与认知功能障碍之间的关联:系统性审查
Mohammed Alpakra1, Nazim F Hamed2, Zainab E Almakki3
1Oncology and Hematology, Armed Forces Hospital Southern Region, Khamis Mushayt, SAU.
Cureus
|October 11, 2024
概括
状细胞贫血 (SCA) 显著影响成人和儿童的认知功能. 早期干预对于预防认知能力下降和提高SCA患者治疗效率至关重要.
科学领域:
- 神经学 神经学
- 血液学 血液学 血液学
- 遗传学 是一个遗传学.
背景情况:
- 状细胞贫血 (SCA) 是一种导致异常血红蛋白分子的血红蛋白病.
- SCA的神经并发症包括认知功能障碍,脑梗塞和中风.
研究的目的:
- 研究状细胞贫血和认知功能障碍之间的关系.
- 确定SCA患者认知功能障碍的患病率和相关因素.
主要方法:
- 在PubMed,MEDLINE,Science Direct和Scopus的系统文献搜索.
- 数据提取和分析由两个独立的审查员.
- 包括18项研究,共有2,457名参与者.
主要成果:
- 成年人的认知功能障碍患病率从11.5%到70%不等,与较低的教育程度,收入,功能,年龄,中风史和血管病变有关.
- 儿童的认知功能障碍患病率从10.2%到68.2%不等,与年龄相关,异常的横多普勒,中风史,缺学和BMI.
- 认知能力下降是所有受SCA影响的年龄组的重要特征.
结论:
- 认知缺陷是状细胞贫血的一个决定性特征,影响所有年龄组.
- 解决认知衰退对于SCA患者医疗干预的有效性至关重要.
- 未来的研究应该探索影响SCA认知的环境和生物因素.
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