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马来西亚马来西亚和中国人群中12个X-STRs位点的种群数据

Aedrianee Reeza Alwi^1,2, Naji Arafat Mahat^3,4,5,6, Faezah Mohd Salleh^1,4

¹Department of Biosciences, Faculty of Science, Universiti Teknologi Malaysia (UTM), 81310 Johor Bahru, Johor, Malaysia.

|October 11, 2024

概括

在马来西亚,X染色体短串重复 (X-STR) 对人类鉴定有价值. 这项研究为马来人和中国人群提供了关键的法医统计数据,增强了他们在复杂的亲属关系案件中的使用.

科学领域:

法医遗传学法医遗传学
人口遗传学人口遗传学
人类识别人类识别

背景情况:

X染色体短串重复 (X-STRs) 越来越多地用于人类识别,特别是在复杂的亲属分析中.
法医统计参数是特定于人群的,需要局部化数据来准确解释.
半岛马来西亚的X-STR人口数据有限,这阻碍了其法医应用.

研究的目的:

确定半岛马来西亚马来人和中国人群中12个X-STR位点的法医统计参数.
评估这些X-STRs在该地区的人类识别和亲属关系分析中的实用性.
评估研究种群相对于其他东南亚群体的生物地理分布.

主要方法:

使用Qiagen Investigator® Argus X-12套件对12个X-STR位点进行基因定型.
对等位基频率的分析和法医统计参数的计算 (例如,区分能力,平均排除机会).
遗传学分析包括遗传距离,邻近连接树和主要成分分析.

主要成果:

DXS10135被确定为最多态的位置.
在马来人和中国人群中报告的高组合歧视力和平均排斥机会值 (等位基和单位基频率).
遗传学分析表明,与其他东南亚人口有密切的生物地理关系.

结论:

这12个X-STR标志物具有高度的信息性,适用于马来半岛马来西亚的马来人和中国人群的法医人类识别.
生成的法医统计数据显著提高了X-STR在马来西亚案例工作中的证据价值.
这些发现支持X-STR分析在东南亚的法医遗传学中的更广泛应用.

关键词:

华人中文华人中文是什么意思法医统计参数的法医统计参数马来西亚马来西亚马来西亚马来西亚马来西亚马来西亚马来西亚马来西亚它们是X-STR.

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