在帕金森病中,大脑结构和结构共变网络的变化与相关的认知障碍有关
Rong-Pei Liu1, Guo-Liang Lin1, Lu-Lu Ma1
1Department of Neurology, Institute of Geriatric Neurology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Frontiers in aging neuroscience
|October 11, 2024
概括
帕金森病的认知障碍 (CI) 与白质,丘脑和海马体体积的减少有关. 结构性大脑网络中断,特别是局部效率下降,与帕金森病 (PD) 中的CI有关.
科学领域:
- 神经成像是一种神经成像.
- 神经科学是一个神经科学.
- 神经学 神经学
背景情况:
- 认知障碍 (CI) 在帕金森病 (PD) 中很普遍.
- 大脑结构和网络相互作用与PD相关的CI有关.
- 磁共振成像 (MRI) 提供了对大脑结构和连接性的非侵入性见解.
研究的目的:
- 研究患有CI和没有CI的PD患者的大脑结构和结构共变性网络的改变.
- 为了比较皮质厚度,皮质下体积和PD患者与没有CI之间的网络拓.
主要方法:
- 招募了18名患有CI的PD患者和33名没有CI的PD患者.
- 评估神经和非运动症状,使用标准化尺度.
- 进行3T结构性MRI测量皮质厚度,皮质下体积和网络拓特性.
主要成果:
- 与没有CI的PD患者相比,患有CI的PD患者表现出较低的白质量,thalamus和海马体积.
- 全脑局部效率下降与PD中的CI相关.
- 皮层厚度和节点网络拓特性在各组之间是相似的.
结论:
- 大脑结构的改变和结构共变性网络的破坏与PD相关的CI有关.
- 这些发现为在帕金森病中图形属性和CI之间的关系提供了新的见解.
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