传统医药在缓解COVID-19症状方面的潜力
Moragot Chatatikun1,2,3, Hiroko P Indo4,5, Motoki Imai6,7
1School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand.
Frontiers in pharmacology
|October 11, 2024
概括
自然化合物显示出治疗COVID-19和预防长期COVID的前景. 植物药物,包括Andrographis paniculata,提供潜在的新疗法,副作用比现有疗法少.
科学领域:
- 病毒学 病毒学
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 变种表现出增加的传染性和免疫逃避.
- 现有的抗病毒药物对某些SARS-CoV-2亚型如BA.2.的有效性有限.
- 在大约10%的患者中,COVID-19会导致长期的COVID和线粒体DNA损伤.
研究的目的:
- 审查COVID-19的预防和治疗策略.
- 确定新的治疗候选者,特别是天然代谢物和植物药物.
- 探索天然产品在管理COVID-19及其并发症方面的潜力.
主要方法:
- 关于COVID-19病原体,变种和治疗方法的研究文献综述.
- 识别和分析具有抗病毒功能的天然代谢物和植物化合物.
- 检查中国传统医学和安德罗格拉菲斯 (Andrographis paniculata) 在COVID-19治疗中的应用.
主要成果:
- 150种天然代谢物被确定为潜在的抗COVID-19候选药物,具有更好的疗效和安全性.
- 植物药物衍生分子在减轻细胞因子风暴和预防肺纤维化方面表现出潜在的潜力.
- 在泰国批准的Andrographis paniculata提取物;在中国广泛用于COVID-19的中国传统中医药.
结论:
- 自然产品,包括植物药物和维生素C和维生素E等补充剂,为COVID-19提供了有前途的辅助疗法.
- 这些天然药物可以减少症状严重程度,抑制病毒活性,并防止长期COVID的进展.
- 由于有限的有效COVID-19治疗方法,基于天然代谢物的药物的进一步开发是有必要的.
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