早期未被识别的SARS-CoV-2引入形成了第一个流行病浪潮,瑞典,2020年
Robert Dyrdak1,2, Emma B Hodcroft3,4, Sandra Broddesson2
1Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.
概括
早期的SARS-CoV-2进入瑞典涉及来自意大利的20A和20B类,以及来自奥地利的19A和20C类. 克莱德20C,可能来自奥地利,主导了第一波,并形成了瑞典集群,突出了对诊断能力的需求.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 基因组监测 基因组监测
背景情况:
- 瑞典经历了严重的COVID-19第一波尽管全球减轻努力.
- 2020年初在瑞典的SARS-CoV-2的引入和传播仍然不完全理解.
研究的目的:
- 在瑞典调查SARS-CoV-2的起源和早期传播动态.
- 为了确定该国COVID-19最初波的病毒类负责.
主要方法:
- 使用PCR检测SARS-CoV-2的储存呼吸器样本 (n=1,979) 的分析.
- 测序PCR阳性标本和植物遗传学分析与全球序列数据相结合.
- 下一个菌株的分类分配和特定突变的识别.
主要成果:
- 确定了12例以前未被识别的SARS-CoV-2病例,最早的样本采集于2020年3月3日.
- 早期的引入包括来自意大利的20A和20B类,以及来自奥地利的19A和20C类.
- 克莱德20C在第一波中占主导地位 (54%),形成了一个具有尖端突变 (G24368T) 的特定国家集群,与早期的COVID-19死亡相关.
结论:
- 在瑞典的社区传播开始之前,缓解努力转移了重点,有利于20C类.
- 引入第20C条款,可能来自奥地利,创造了传输优势.
- 疫情防控需要全面的诊断,以便及早发现与旅行有关的病例和社区传播.
更多相关视频
相关概念视频
00:57Viral Recombination
23.3K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.3K
01:18Steps in Outbreak Investigation
108
In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
108
00:36Viral Mutations
32.2K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
32.2K
01:03Rous Sarcoma Virus (RSV) and Cancer
5.0K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.0K