涉及的领域高剂量化疗与呼吸运动管理对于食道状细胞癌的食道状细胞癌
Masaki Matsuda1, Takafumi Komiyama1, Kan Marino1
1Department of Radiology, University of Yamanashi, Chūō, Yamanashi, Japan.
Thoracic cancer
|October 11, 2024
概括
高剂量化学放射治疗与运动管理在食道癌症方面表现有前途. 仔细的风险评估对于在这种先进治疗中选择患者至关重要.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
背景情况:
- 食道状细胞癌 (ESCC) 存在重大治疗挑战.
- 高剂量涉及场化学放射治疗 (CRT) 与呼吸运动管理是一种不断发展的策略.
研究的目的:
- 评估高剂量涉及现场CRT与ESCC患者的呼吸运动管理相结合的临床结果.
- 评估与这种方法相关的治疗疗效,失败模式和毒性.
主要方法:
- 对35名ESCC患者的回顾性分析,这些患者在2012-2018年间接受了终极CRT (≥66 Gy) 治疗.
- 呼吸运动管理包括屏息 (63%) 和面具固定 (29%).
- 使用内镜剪切标记器的光学评估瘤运动;评估了患者的特征,疗效,失败模式和毒性.
主要成果:
- 总体应答率为94.3%,随访时间中位数为43个月.
- 两年生存率:整体生存率 (OS) 51.4%,无进展生存率 (PFS) 42.9%,局部无故障生存率 (LRFFS) 42.9%.
- 食道显著影响了OS (p=0.002);主要的毒性包括细胞衰竭和狭窄. 支气管/气管压缩和更高的剂量 (70 Gy) 与管相关.
结论:
- 涉及的高剂量CRT与呼吸运动管理似乎是可行的ESCC.
- 对食道风险的全面评估对于选择适合这种治疗的候选人至关重要.
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