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Updated: Jun 10, 2025

Rapid and Robust Analysis of Cellular and Molecular Polarization Induced by Chemokine Signaling
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Published on: December 12, 2014

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由结构极性启动的细胞极化化学机械模型

Hexiang Wang1, Zhimeng Jia2, Yuqiang Fang1

  • 1School of Mechanical and Aerospace Engineering, Jilin University, Changchun, China. yuqiangfang@jlu.edu.cn.

Soft matter
|October 11, 2024
PubMed
概括

细胞极化对于细胞功能至关重要,由结构极性启动. 这项研究模拟了初始细胞结构和Cdc42信号如何在不同的细胞外矩阵刚度上驱动极化和durotaxis.

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Cell Polarization by Rho Proteins01:21

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Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
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A permanent electric dipole orients itself along an external electric field. This rotation can be quantified by defining the potential energy because the external torque does work in rotating it. Then, the potential energy is minimum at the parallel configuration and maximum at the antiparallel configuration. While the former is a stable equilibrium, the latter is an unstable equilibrium.
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