根据横向性,年龄,种族和民族的第二次原发性乳腺癌的风险因素
Esther M John1,2,3, Jocelyn Koo3, Sue A Ingles4,5
1Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, United States.
Journal of the National Cancer Institute
|October 11, 2024
概括
第二种原发性乳腺癌 (SBC) 的危险因素因年龄而异. 年轻女性面临来自ER/PR阴性瘤和家族病史的更高风险,而老年女性更容易受到家族病史,绝经前状态和生活方式因素的影响.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 癌症研究 癌症研究
背景情况:
- 以前对第二次原发性乳腺癌 (SBC) 的流行病学研究主要集中在非西班牙裔白人 (NHW) 女性身上.
- 了解不同人群中的风险因素对于公平的癌症护理至关重要.
研究的目的:
- 调查与逆侧 (CSBC) 和逆侧 (ISBC) 第二次原发性乳腺癌相关的临床和流行病学风险因素.
- 检查这些协会跨不同的年龄组和种族/种族背景.
主要方法:
- 分析了9639名患有第一次原发性侵袭性乳腺癌 (FBC) 的女性的多样化,基于人口的队列.
- 来自加利福尼亚癌症登记处的数据被用于识别618例CSBC和278例ISBC病例,这些病例在FBC诊断后超过6个月.
- 精细和灰色的竞争风险模型被用来评估风险因素的关联.
主要成果:
- 在年轻女性 (<50岁) 中,较高的CSBC风险与ER/PR阴性FBC,家族病史和无双性有关. 年龄较大的女性 (≥50岁) 患有家族病史,绝经前状态,超重和酒精消费的风险增加.
- 侧SBC (ISBC) 风险与年轻女性的婚姻状况和年长女性的超重相关.
- 虽然CSBC风险估计在种族/种族群体中相似,但与NHW女性相比,年轻的非裔美国人,亚裔美国人和西班牙裔女性以及年长的非裔美国人和西班牙裔女性 (ER/PR阳性FBC) 的风险仍然很高.
结论:
- 研究结果表明,需要对SBC风险较高的女性进行遗传风险评估,量身定制的查和生活方式修改.
- 其他尚未确定的风险因素可能会导致跨种族和民族群体观察到的SBC负担的差异.
相关概念视频
Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
Cancer Survival Analysis
328
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
328
Skin Cancer
3.9K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
3.9K
Cancers Originate from Somatic Mutations in a Single Cell
11.8K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
11.8K
Cancer-Critical Genes II: Tumor Suppressor Genes
7.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.3K


