与多发性硬化症和认知障碍患者的动态网络变化相关的能量
Tommy A A Broeders1, Maureen van Dam1, Giuseppe Pontillo1
1From the MS Center Amsterdam (T.A.A.B., M.v.D., V.R., L.D., Y.D.v.d.W., C.H.V., M.M.S.), Anatomy & Neurosciences, and MS Center Amsterdam (G.P., F.B.), Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (G.P., F.B.), University College London, United Kingdom; Departments of Advanced Biomedical Sciences and Electrical Engineering and Information Technology (G.P.), University of Naples "Federico II," Italy; MS Center Amsterdam (J.K.), Neurology, and MS Center Amsterdam (C.H.V.), Psychiatry, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc; Amsterdam Public Health (C.H.V.), Mental Health Program; and GGZ inGeest Mental Health Care (C.H.V.), Amsterdam, the Netherlands.
由于能源成本较高,认知障碍多发性硬化症 (MS) 患者的脑网络状态转变频率较低. 具体来说,从默认模式网络向视觉网络的转移受到显著影响,影响了认知功能.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 医疗成像医学成像
背景情况:
- 多发性硬化症 (MS) 经常导致认知障碍.
- 在MS的认知障碍与大脑的结构和功能变化有关.
- 功能性大脑网络动态改变对MS认知功能的影响尚不清楚.
研究的目的:
- 确定与MS认知障碍相关的动态功能网络模式.
- 调查是否改变了能源成本解释这些网络模式在认知障碍 (CI) 的MS患者.
- 确定网络过渡与MS认知状态之间的关系.
主要方法:
- 利用来自阿姆斯特丹MS队列的静止状态功能和扩散MRI.
- 将多发性硬化患者分为认知障碍 (CI),轻度CI (MCI) 和认知保存 (CP) 组.
- 通过使用k-means集群分析功能连接状态,并通过网络控制理论计算过渡控制能量.
主要成果:
- 与CP患者相比,CI MS患者在功能连接状态之间过渡的频率较低.
- 在CI患者中,从默认模式网络状态到视觉网络状态的过渡有显著的减少.
- 认知障碍的多发性硬化症患者需要更多的控制能量来进行状态过渡,特别是维持特定状态.
结论:
- 动态网络重新配置的更高能源成本可能是认知障碍多发性硬化患者减少状态过渡的基础.
- 障碍过渡,特别是从默认模式到视觉网络的过渡,与MS的认知功能有关.
- 建议进行纵向研究,以了解这些网络干扰在疾病不同阶段的进展情况.
更多相关视频
09:01A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
Published on: May 7, 2014
06:37Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
Published on: July 14, 2023
相关概念视频
Cognitive Development During Adulthood
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
