长期暴露于第三方烟雾可能通过线粒体功能障碍加速生物衰老:来自人口和动物研究的证据
Wenbo Jiang1, Xin Liu1, Qianqian Lei2
1Department of Nutrition and Food Hygiene, School of Public Health, Key Laboratory of Precision Nutrition and Health, Ministry of Education, Harbin Medical University, 157 Baojian Road, Harbin, Heilongjiang 150081, China.
Journal of hazardous materials
|October 11, 2024
概括
第三手烟 (THS) 暴露显著加快生物衰老,增加生物年龄超过3年. 这种环境毒素还缩短了寿命,正如Drosophila模型所示,突出了它对健康的有害影响.
科学领域:
- 环境健康 环境健康
- 老年学是指老年学的学科.
- 毒理学 毒理学 毒理学
背景情况:
- 第三手烟雾 (THS) 包含烟草烟雾消散后在表面留下的残留化学物质.
- 暴露于THS对人类衰老和寿命的影响尚不清楚.
- 调查THS影响对于公共卫生至关重要,因为广泛暴露.
研究的目的:
- 研究THS暴露对生物衰老标志物的影响.
- 用模型生物来确定THS对寿命的影响.
- 为了确定THS诱导的衰老背后的分子机制.
主要方法:
- 对986名非吸烟者的血液老化标志物的横截面分析.
- 在暴露于THS的Drosophila melanogaster模型中的寿命评估.
- 蛋白质和代谢分析,以确定关键的分子参与者和途径.
- 在体外实验验验证细胞机制.
主要成果:
- 暴露于THS显著加速了生物衰老,使生物年龄平均增加3.04年 (p < 0.05).
- 暴露于THS的果虫的寿命缩短了16.07天 (p < 0.01).
- 确定MRPL2是THS诱导衰老的关键蛋白质,与线粒体功能障碍和氧化应激有关.
- 代谢分析揭示了能量代谢途径的破坏.
结论:
- 暴露于THS是衰老过程的显著加速剂.
- THS对寿命和细胞能量代谢产生负面影响.
- 在调解THS的衰老影响方面,MRPL2起着至关重要的作用.
- 这些发现为与环境烟雾残留相关的健康风险提供了新的见解.
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