相关实验视频
Updated: May 3, 2026
07:27
Olfactory Assays for Mouse Models of Neurodegenerative Disease
Published on: August 25, 2014
21.9K
嗅觉功能障碍降低了奖励系统中的局部现场潜力,并增加了小鼠的EtOH消耗
Jianhong Zhou1, Di Luo2, Yingjie An2
1Department of Basic Medicine, Medical School, Kunming University of Science and Technology, Kunming, Yunnan, 650550, China; Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, Yunnan, 650550, China.
Neurochemistry international
|October 11, 2024
概括
嗅觉功能障碍,或嗅觉丧失,增加了小鼠的酒精消费和偏好. 这与大脑奖励系统活动的变化有关,为酒精成神经生物学提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 成研究 研究成研究
背景情况:
- 慢性饮酒会损害嗅觉敏度和辨识能力.
- 酒精的气味起到了诱导成的记忆和渴望的作用.
- 嗅觉障碍对饮酒的影响尚不清楚.
研究的目的:
- 调查嗅觉功能障碍如何影响乙醇消费和偏好.
- 为了检查在嗅觉损失期间大脑奖励系统活动的变化.
- 了解与气味有关的酒精成的神经生物学基础.
主要方法:
- 小鼠使用硫酸 (ZnSO4) 进行了嗅觉上皮损伤.
- 乙醇 (EtOH) 消耗量被测量使用两瓶选择和在黑暗中饮酒 (DID) 测试.
- 当地场潜力 (LFPs) 记录来自腹膜区域 (VTA),内核 (NAc) 和皮质状皮质 (Pir).
主要成果:
- 嗅觉功能障碍导致EtOH消费和偏好增加.
- 损伤后一周,LFP在奖励系统中的力量下降了,皮质皮质和奖励区域之间的连贯性也下降了.
- 损伤后四周,LFP功率正常化,但VTA-NAc一致性下降,表明持久的影响.
结论:
- 嗅觉缺陷显著增加了小鼠的乙醇消耗.
- 改变LFP功率和奖励系统中的连贯性伴随着嗅觉功能障碍.
- 这些发现表明嗅觉功能障碍改变了奖励系统的活动,影响了寻求奖励的行为和酒精成.
相关概念视频
01:25Olfaction
40.5K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
40.5K
01:03Olfactory Receptors: Location and Structure
10.5K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
10.5K