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Updated: Jun 10, 2025

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
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富含白的α-2-糖蛋白 1 通过人体表皮生长因子受体3信号传递促进转移性结肠直肠癌的生长

Moeez Rathore1, Kimberly Curry1, Wei Huang2

  • 1Department of Surgery, Case Western Reserve University, Cleveland, Ohio; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio.

Gastroenterology
|October 11, 2024
PubMed
概括

富含白的α-2-糖蛋白1 (LRG1) 在肝脏微环境中激活人体表皮生长因子受体3 (HER3),促进转移性结直肠癌 (mCRC) 的生长. 针对这种新的LRG1-HER3通路为mCRC提供了一个新的治疗策略.

关键词:
胃肠道癌 胃肠道癌肝脏转移的发生.肝脏微环境 肝脏微环境副内的情况.

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