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Updated: Jun 10, 2025

A Tailored HPLC Purification Protocol That Yields High-purity Amyloid Beta 42 and Amyloid Beta 40 Peptides, Capable of Oligomer Formation
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Published on: March 27, 2017

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粉胺β (1-40) 寡合物的临界聚合度和可逆性

Sara Illodo1, Wajih Al-Soufi2, Mercedes Novo2

  • 1Facultade de Ciencias, Departamento de Química Física, Campus Terra, Universidade de Santiago de Compostela, 27002, Lugo, Spain; Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS) and Facultade de Química, Departamento de Química Física, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.

Archives of biochemistry and biophysics
|October 11, 2024
PubMed
概括

粉样蛋白-β40 (Aβ40) 聚合发生在两个阶段,形成寡合体和原纤维. 这种阿尔茨海默病蛋白质的聚合倾向低于Aβ42,具有可逆早期寡合体.

关键词:
粉样蛋白聚合物的聚合.粉样蛋白-β 14040 的情况.光相关谱法 光相关谱法

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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