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在乳腺癌和Ki-67表达的非侵入性评估中的多模态明显扩散MRI模型

Huan Chang¹, Jinming Chen¹, Dawei Wang²

¹Department of Radiology, Shandong Provincial Qianfoshan Hospital, Shandong University, No.16766 Jingshi Road, Jinan, Shandong, China.

Cancer imaging : the official publication of the International Cancer Imaging Society

|October 11, 2024

概括

多模态明显扩散 (MAD) 权重的MRI有效地区分恶性与良性乳腺病变. 这种先进的MRI技术也显示出预测Ki-67表达水平的前景,这对于乳腺癌治疗决策至关重要.

科学领域:

放射学放射学是一门学科.
在瘤学瘤学.
医疗成像医学成像

背景情况:

区分恶性和良性乳腺病变对于适当的患者管理至关重要.
在手术前预测Ki-67的表达可以指导乳腺癌的治疗策略.

研究的目的:

评估多模态明显扩散 (MAD) 权重MRI在区分恶性和良性乳腺病变方面的能力.
评估MADMRI在预测乳腺癌患者Ki-67表达水平方面的实用性.

主要方法:

对93名确诊乳腺病变的患者进行了回顾性分析.
多模态明显扩散 (MAD) 图像是使用3.0TMRI扫描仪获得的,具有16b值.
使用曼·惠特尼U测试和ROC曲线分析计算和分析了各种MAD参数 (fF,DF,fUI,fH,DH,αH,fr,dr).

主要成果:

与良性病变相比,在恶性病变中观察到显著更高的fR和较低的fUI和DH (P < 0.001).
组合的MAD参数 (fR,DH,fUI) 在区分病变类型时达到0.851的最高AUC.
高基-67表达与较低的DH,较高的DF和较高的αH (P <0.05) 相关,组合参数为0.691的预测AUC.

结论:

多模态明显扩散 (MAD) 权重的MRI是诊断乳腺病变的宝贵工具.
在乳腺癌中,MAD MRI显示了对Ki-67表达水平在手术前预测的潜力.

关键词:

乳腺癌乳腺癌乳腺癌扩散磁共振成像技术的研究.多式联络式明显扩散分析.

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