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在β-血病患者的肠道微生物群的不同组成及其与铁过载的相关性

Poochit Nonejuie¹, Alisa Wilantho², Daniel McDonald³

¹Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand.

Scientific reports

|October 11, 2024

概括

与健康个体相比,血病患者的肠道微生物群显示出减少的多样性和独特的细菌组成. 这些肠道微生物组的变化与较高的铁含量相关,并可能影响疾病管理.

科学领域:

微生物组研究的研究.
血液学血液学血液学
胃肠病学胃肠病学

背景情况:

肠道微生物群显著影响健康和疾病.
thalassemia需要输血,导致铁过载.
铁的积累可能会改变肠道微生物群,增加血病患者的感染风险.

研究的目的:

为了研究非输血依赖 (NTDT) β-thalassemia/HbE患者的便微生物群组成.
为了将NTDT β-thalassemia/HbE患者的肠道微生物组与健康对照进行比较.
评估铁化对这些患者肠道微生物群的影响.

主要方法:

分析了70名NTDT β-thalassemia/HbE患者和30名健康对照的便微生物群.
横截面研究设计. 截面研究设计.
微生物组概况和与费里水平的相关性分析.

主要成果:

铁化没有对微生物组概况产生可检测的影响.
与对照组相比,thalassemia患者表现出显著减少的细菌多样性和独特的社区结构.
在患者中减少了短链脂肪酸产生细菌 (如Alistipes,Coprococcus,Oscillospira,Ruminococcaceae) 的流行,增加了不健康的肠道相关细菌 (如Clostridium,Fusobacteriaceae,Enterobacteriaceae,Peptostrptococcaceae) 的流行.
某些细菌种群的患病率增加与更高的费里水平相关.

结论:

在NTDT β-thalassemia/HbE患者中,肠道微生物群的改变是明显的.
这些因多样性减少和细菌特异性转移而表现出的失生变化与高水平的费里相关.
微生物组的变化可能作为铁过载的标志物,并可能间接影响血病共患病的管理.

关键词:

铁过载是因为铁过载.微生物组是一个微生物组.泰拉西米亚泰拉西米亚

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