空鼻综合征与喉回流病之间的关联:一项初步队列研究
Jerome R Lechien1,2,3,4, Miguel Mayo-Yanez5, Carlos M Chiesa-Estomba6
1Department of Surgery, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium. Jerome.Lechien@umons.ac.be.
概括
患有空鼻综合征 (ENS) 的患者表现出明显更高的喉回流病 (LPRD) 症状. 这项研究强调了ENS和LPRD之间的强烈关联,建议通过客观措施进一步调查.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 胃肠病学 胃肠病学
- 症状学研究 症状学研究
背景情况:
- 空鼻综合征 (ENS) 是一种复杂的疾病,其特征是矛盾的鼻腔阻塞.
- 喉喉逆流性疾病 (LPRD) 涉及胃酸逆流,影响喉和喉.
- 需要进一步阐明ENS和LPRD之间的关系.
研究的目的:
- 调查喉回流病 (LPRD) 与空鼻综合征 (ENS) 之间的潜在关联.
- 评估在被诊断为ENS的患者中LPRD症状的流行率.
主要方法:
- 使用了包括RSS-12,NOSE,ENS6Q,ENSI和SNOT-22在内的验证问卷来评估症状.
- 使用GAD-7和PHQ-9评估焦虑和抑郁.
- 在ENS患者和对照组 (鼻炎/鼻炎和无症状个体) 之间比较症状得分和LPRD患病率.
主要成果:
- 在ENS患者中观察到疑似LPRD的高患病率 (90.2%),明显高于对照组.
- 鼻腔系统患者报告鼻腔阻塞和反流症状的得分明显更高 (RSS-12,NOSE,SNOT-22).
- 在反流症状得分 (RSS-12) 和ENS严重性指数 (ENS6Q,ENSI) 之间发现了强烈的相关性.
结论:
- 在患有空鼻综合征的患者中,LPRD的症状和患病率显著增加.
- 建议采用客观诊断方法的进一步研究,如阻抗-pH监测,以确认ENS中的LPRD患病率.
- 这些发现表明,潜在的联系需要在ENS管理中对LPRD进行临床考虑.
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