来自早产婴儿营养来源的脂肪酸及其对血脂肪酸概况的影响
Gerhard Fusch1, Naomi H Fink1, Niels Rochow1
1Division of Neonatology, Department of Pediatrics, McMaster University, Hamilton, ON, Canada.
Molecular and cellular pediatrics
|October 11, 2024
概括
过早出生的婴儿表现出血脂肪酸概况的改变,一些脂肪比他们的饮食低,而另一些脂肪比他们的饮食高. 这些婴儿的高甘油三血可能涉及选择性脂肪积累,指导未来的营养策略.
科学领域:
- 新生儿营养新生儿营养
- 生物化学 生物化学
- 儿科重症监护室的重症监护室是儿童重症监护室.
背景情况:
- 在早产婴儿中,通过肠道输入脂肪可以导致过高甘油三血症,这与肠道输入方式不同.
- 推的亲肠道脂肪摄入量低于母乳所能达到的水平.
- 导致过高甘油三血症的特定脂肪酸变化尚不清楚.
研究的目的:
- 为了比较早产婴儿血中的脂肪酸概况与它们的营养来源 (母乳和脂质乳液).
- 为了研究母乳养婴儿与脂质乳液乳液之间的血脂肪酸概况差异.
- 为了识别正常与升高的甘油三水平的婴儿脂肪酸概况的变化.
主要方法:
- 在47名早产婴儿 (<36周妊娠期) 中使用气色谱/质谱分析血清脂肪酸概况.
- 婴儿血脂肪酸概况与相应的营养摄入量 (母乳,脂质乳液) 的比较.
主要成果:
- 血脂肪酸概况与饮食来源不同,一些脂肪酸 (例如C8:0,C10:0) 显著低,而其他脂肪酸 (例如C16:0,C18:0) 比母乳高.
- 在母乳养婴儿与脂质乳液缩之间,血脂肪酸概况没有明显的差异.
- 过高甘油三血与特定脂肪酸水平升高有关,特别是C18:1n9和C16:0.
结论:
- 早产婴儿的血脂质概况显示出特定脂肪酸的选择性耗尽和丰富,而不是直接反映饮食摄入量.
- 过高 triglyceridemia 可能代表选择性脂肪酸积累的状态,需要进一步研究脂肪酸流量.
- 更好地了解脂肪酸代谢可以为开发更平衡的亲肠道营养提供信息,以改善早产婴儿的临床结果.
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