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在严重创伤性脑损伤患者中,可溶性编程死亡-1和可溶性编程死亡联体-1的预后值
Lei Liu1, Pengpeng Lan2, Guiping Wu2
1Department of Internal Medicine, the Affiliated Hospital of China University of Petroleum (East China), Qingdao, 266580, China.
Scientific reports
|October 11, 2024
概括
在严重创伤性脑损伤 (TBI) 患者中,可溶性编程死亡-1 (sPD-1) 和可溶性编程死亡联体-1 (sPD-L1) 的含量升高. 这些生物标志物预测严重的肺炎和死亡率,为早期干预提供了潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
- 临界护理医学 临界护理医学
背景情况:
- 创伤性脑损伤 (TBI) 通常导致免疫抑制.
- 对TBI并发症的预测生物标志物对于患者管理至关重要.
研究的目的:
- 评估可溶性编程死亡-1 (sPD-1) 和可溶性编程死亡联体-1 (sPD-L1) 作为严重TBI患者严重肺炎和死亡率的预测因子.
主要方法:
- 周围血液中的sPD-1和sPD-L1水平在入院后48小时内测量了82名严重TBI患者和20名健康对照组.
- 统计分析,包括曲线下面积 (AUC) 计算,用于评估预测值.
主要成果:
- 与对照组相比,严重TBI患者的sPD-1和sPD-L1水平显著上调 (P < 0.001).
- 较高水平与严重的肺炎,死亡率 (P < 0.001),格拉斯哥昏迷尺度 (GCS) 分数较低,APACHE II分数较高和机械通风持续时间较长有关.
- 预测严重肺炎的AUC为0.714 (sPD-1) 和0.696 (sPD-L1);对于死亡率,它们为0.758 (sPD-1) 和0.735 (sPD-1).
结论:
- 在严重的TBI中,sPD-1和sPD-L1的升级与严重的肺炎和死亡率的风险增加有关.
- sPD-1和sPD-L1是这些不良结果的独立预测因素.
- 这些生物标志物显示出预测TBI患者严重肺炎和死亡率的潜力.
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