孕产妇脂肪和围产和后代的结果:一个总体审查
Ziyi Yang1, Gengchen Feng1, Xueying Gao2,3,4
1State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, China.
Nature human behaviour
|October 11, 2024
概括
孕产妇肥胖与不良的周产期和后代结果有关,包括增加出生并发症和发育问题的风险. 虽然一些干预措施有所帮助,但对因果关系和广泛干预有效性的令人信服的证据仍然有限.
科学领域:
- 生殖健康 生殖健康
- 儿科 儿科 儿科
- 公共卫生 公共卫生
背景情况:
- 孕产妇肥胖症对产科健康和长期后代福祉构成风险.
- 现有的研究提供了关于这些关联的复杂图片.
研究的目的:
- 对观察性,门德尔随机化和干预性元分析进行总体审查.
- 评估将母体肥胖与围产期和后代结局联系在一起的证据.
主要方法:
- 包括194个观察性元分析,10个门德尔随机化研究和748个干预性元分析.
- 使用证据分级来评估协会的实力.
主要成果:
- 有令人信服的证据将母亲的肥胖与12种不良结果联系在一起 (例如,剖腹产,婴儿死亡率,后代肥胖).
- 母亲减肥干预减少了产前抑郁症,但没有减少后代脂肪.
- 门德尔的随机化研究支持妊娠糖尿病,孕前和出生大小的因果关系.
结论:
- 观察性研究表明关联,但令人信服的因果证据有限.
- 孕产妇减肥干预措施对围产期结果提供了部分好处.
- 需要进一步的研究来澄清因果途径和干预疗效.
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