在学龄前儿童中早产与喘和亚托皮炎之间的关联:一项基于全国人口的全国性研究
Jong Ho Cha1, Jae Kyoon Hwang2,3, Jae Yoon Na1,3
1Department of Pediatrics, Hanyang University Seoul Hospital, Hanyang University College of Medicine, Seoul, Korea.
过早分娩增加了儿童的喘风险,特别是对于那些出生极早的婴儿. 相反,早产与亚托皮炎风险较低有关,心肺呼吸系统疾病是喘的主要风险因素.
科学领域:
- 儿科 儿科 儿科
- 新生儿科学 新生儿科学
- 过敏和免疫学 过敏和免疫学
背景情况:
- 喘和亚托邦性皮肤炎 (AD) 是常见的儿童慢性疾病.
- 过早分娩是喘的已知风险因素,但其与AD的关联不太清楚.
- 对这些关系进行的大规模全国性研究是有限的.
研究的目的:
- 调查早产对儿童喘和AD发病率和严重性的影响.
- 为了确定与早产婴儿喘和AD相关的新生儿风险因素.
- 分析妊娠年龄与喘和AD风险之间的关联.
主要方法:
- 利用韩国国家健康保险服务数据 (2007-2014) 对2,224,476名婴儿.
- 将婴儿分为极度早产 (EP, <28周 GA),其他早产 (OP, 28-36周 GA) 和全产 (FT, >37周 GA) 组.
- 使用治疗加权多变量考克斯回归的逆概率来评估关联.
主要成果:
- 过早分娩显著增加了喘风险 (OP的aHR为1.24,EP的1.51) 和降低了AD风险 (OP的aHR为0.73,EP的0.88).
- 心血管疾病 (RDS,BPD,PDA,肺高血压) 是重要的喘风险因素,尤其是严重和早期喘的BPD.
- 新生儿败血症,黄和早产视网膜病变也增加了喘风险.
结论:
- 过早生育的孩子面临着更高的喘风险和更低的阿尔茨海默病风险.
- 新生儿的心肺呼吸道并发症是发展喘的关键风险因素.
- 针对性呼吸管理策略对于早产婴儿至关重要,因为他们更容易患喘.
更多相关视频
06:47Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
Published on: September 27, 2017
07:36Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
相关概念视频
Asthma-I: Introduction
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-III: Symptoms and Complications
Classification of Asthma
Autism Spectrum Disorder
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
