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Updated: Jun 10, 2025

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Oral Biofilm Sampling for Microbiome Analysis in Healthy Children
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头60个月口腔微生物群的发展:一个纵向研究
K Yama1, S Morishima2, K Tsutsumi1
1Research and Development Headquarters, Lion Corporation, Edogawa-ku, Tokyo, Japan.
Journal of dental research
|October 12, 2024
概括
儿童的口腔微生物群在6至18个月之间显著发展,在36个月时接近成人水平. 这种早期的成熟期对未来的口腔健康至关重要.
科学领域:
- 微生物学 微生物学
- 儿科 儿科 儿科
- 基因组学就是基因组学.
背景情况:
- 儿童时期对于建立终身口腔微生物群组成至关重要.
- 儿童口腔微生物群发育的确切时间表尚不清楚.
研究的目的:
- 纵向跟踪儿童口腔微生物群形成的进展.
- 确定口腔微生物群落的关键发展窗口.
主要方法:
- 54名儿童 (1周至5岁) 唾液微生物群的长度研究.
- 16S rRNA V1-V2区域的下一代测序.
- 分析常用的操作分类单位 (OTU) 和UniFrac距离指标.
主要成果:
- 主要组成细菌的检测率从一周后的25%增加到6-18个月后的80%,到36个月后达到90%.
- 早期的殖民者 (1周) 包括链球菌,Rothia和Gemella;后来的殖民者 (6-18个月) 包括Neisseria,Haemophilus和Fusobacterium.
- 儿童的口腔微生物群在6-18个月之间接近成年人形状,在60个月时完全成熟.
结论:
- 前36个月,特别是6-18个月,是儿童口腔微生物群成熟的关键时间.
- 早期口腔微生物群的发展可能在预防未来的口腔疾病方面发挥着至关重要的作用.
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