在炎症性肠病的发病过程中对T细胞反应的调节失调
Rucha Chandwaskar1, Rajdeep Dalal2, Saurabh Gupta3
1Amity Institute of Microbial Technology (AIMT), Amity University Jaipur, Rajasthan, India.
Scandinavian journal of immunology
|October 12, 2024
概括
炎症性肠病 (IBD) 涉及免疫系统失调,特别是辅助T (Th) 细胞. 本综述研究了Th细胞子集和其他T细胞在IBD病原和潜在疗法中的作用.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 炎症性肠病 (IBD),包括克罗恩病 (CD) 和性结肠炎 (UC),在全球范围内越来越普遍,特别是在印度等东部国家.
- IBD的发病包括免疫反应失调,T辅助 (Th) 细胞子集及其细胞因子起着关键作用.
- 肠道微生物群,饮食和宿主基因等因素显著影响IBD的严重程度和进展.
研究的目的:
- 审查各种T辅助 (Th) 细胞子集在与IBD相关的肠道炎症中的作用.
- 讨论其他T细胞类型,包括CD8+T细胞,NKT细胞和γδT细胞在IBD中的参与.
- 根据T细胞参与来确定IBD的潜在治疗点.
主要方法:
- 文献综述侧重于T细胞子集及其在IBD中的细胞因子.
- 分析效应细胞和调节性T细胞在驱动肠道炎症中的相互作用.
- 检查导致IBD的环境和遗传因素.
主要成果:
- 在IBD患者中观察到效应器Th细胞子集 (Th1,Th17,Th9) 的水平增加.
- 效应细胞和调节性T细胞之间的调节失调对IBD的发病有显著的贡献.
- 特定的T细胞子集及其相关的细胞因子与IBD的炎症过程有关.
结论:
- 辅助T细胞子集是IBD中所见的免疫失调的核心.
- 了解多种T细胞群 (Th,CD8+,NKT,γδT) 的作用,可以了解IBD.
- 准特定的T细胞通路为管理IBD提供了有前途的治疗途径.
相关概念视频
01:30Inflammatory Bowel Disease II: Crohn's Disease
191
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
191
01:24T Cell Types and Functions
959
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
959
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
147
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
147
01:28Inflammatory Response
1.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
1.9K
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
117
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
117
01:17Chronic Bowel Disorders: Introduction
397
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
397