在接受化疗辐射的头癌患者中进行败血症监测
Ajay Babu1, Hadrian Noel Alexander F1, Sandeep Muzumder2
1Department of Radiation Oncology, St. John's Medical College and Hospital, Bengaluru, Karnataka, India.
概括
败血症监测和及时干预,包括抗生素和G-CSF,在接受化疗或放射治疗的头癌患者中显著减少了与败血症相关的死亡. 早期住院是改善结果的关键.
科学领域:
- 在瘤学瘤学.
- 传染病管理 传染病管理
背景情况:
- 接受化疗放射治疗 (CRT) 的头癌 (HNC) 患者面临着严重的感染风险,以前在类似患者队列中观察到与败血症相关的死亡率为12%.
- 这一群体的一般感染率约为19%,败血症导致3%至9%的死亡.
研究的目的:
- 评估结合败血症监测计划与早期干预策略的有效性,以减少接受CRT的局部高级HNC患者的败血症相关死亡率.
- 分析抗生素,G-CSF和早期住院治疗在CRT期间治疗败血症的利用情况.
主要方法:
- 在2018年1月至2021年12月期间接受CRT的54名本地高级HNC患者的回顾性分析.
- 收集的数据包括败血症监测协议,抗生素和G-CSF (口服和静脉注射) 管理,早期入院的原因和早期死亡率.
- 使用SPSS v.24.4.进行统计分析.
主要成果:
- 门诊口服抗生素给了38.9%的患者,G-CSF给了25.9%的患者. 54%的患者需要住院治疗,其中96%接受了静脉注射抗生素,62%接受了G-CSF.
- 在8例病例中,由于持续发烧和中性衰竭,强化了抗生素治疗. 干预的中位时间是CRT的第五周.
- 只有1名患者 (1.9%) 死于败血症,与以前的比率相比,这一比例显著下降. 89%完成了放射治疗,25.9%完成了化疗.
结论:
- 实施败血症监测和及时干预,包括抗生素和G-CSF,以及适时早期住院治疗,有效地减少了接受CRT的HNC患者的败血症相关早期死亡.
- 这种综合方法可以在苛刻的癌症治疗过程中改善患者的治疗结果和治疗完成率.
更多相关视频
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
11.4K
07:30Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
10.0K
相关概念视频
01:23Tracheostomy Suctioning II: Procedure
178
Tracheostomy suctioning is a vital nursing procedure that involves removing secretions from the tracheostomy tube to maintain airway patency and prevent respiratory complications. Nurses need to understand the proper technique for tracheostomy suctioning to ensure patient safety and comfort. In this guide, we will outline the step-by-step process for performing tracheostomy suctioning, including preparing the sterile field, donning personal protective equipment (PPE), lubricating and connecting...
178
01:20Sputum Studies II: Culture and Sensitivity
268
Description
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
268
01:26Endoscopic Studies II: Thoracocentesis
208
Thoracentesis(Thoracocentesis), commonly known as pleural tap, is a medical procedure where a 22 gauge needle is inserted into the pleural space, the area between the lung and chest wall. This procedure is commonly performed to diagnose or treat various respiratory disorders.
Description
Excess pleural fluid or air may accumulate in some respiratory disorders in the thoracic cavity. To treat pleural effusion, a physician conducts thoracentesis by carefully piercing the chest wall and entering...
Description
Excess pleural fluid or air may accumulate in some respiratory disorders in the thoracic cavity. To treat pleural effusion, a physician conducts thoracentesis by carefully piercing the chest wall and entering...
208
01:22Healthcare Associated Infections II: Preventive Measures
2.5K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.5K
01:22Aneurysm IV: Nursing Management
3
Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
3