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在葡萄牙中部的HIV-2感染者中,E型肝炎病毒的流行率

João Pereira-Vaz¹, Anália Carmo², Vítor Duque^3,4

¹Laboratory of Virology, Clinical Pathology Department, Centro Hospitalar e Universitário de Coimbra, Unidade Local de Saúde de Coimbra, Avenida Afonso Romão, Coimbra, 3000-602, Portugal. joaovaz@ulscoimbra.min-saude.pt.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

|October 12, 2024

概括

肝炎E病毒 (HEV) 感染的发病率在患有人类免疫缺陷病毒2 (HIV-2) 的人和一般人群中相似. 没有发现HIV-2是HEV感染或慢性HEV的风险因素.

科学领域:

病毒学病毒学
传染性疾病传染性疾病
免疫学免疫学免疫学

背景情况:

肝炎E病毒 (HEV) 是全球急性和慢性肝病的重要原因.
人类免疫缺陷病毒2 (HIV-2) 感染在某些人群中很普遍,可能会对免疫反应产生影响.
关于HIV-2感染人口中HEV患病率和风险因素的数据有限.

研究的目的:

为了确定葡萄牙中部HIV-2感染者的HEV感染的血清流行率.
为了比较HIV-2人群中的HEV患病率与匹配的一般人群对照组.
研究HIV-2患者的HEV感染和临床参数之间的潜在关联.

主要方法:

横截面研究设计. 截面研究设计.
对HEV抗体 (抗HEVIgM/IgG) 的血清检测.
在HIV-2患者和匹配的健康对照组之间的HEV血清阳性率的比较.
对CD4细胞计数,HIV-2病毒载量,地理来源和旅行史的关联进行分析.

主要成果:

在HIV-2患者中,HEV血清阳性在19.4%的人群中被观察到.
在HIV-2组和匹配的对照人群之间没有发现HEV血清流行率的显著差异.
高血压病毒阳性与CD4细胞计数,HIV-2病毒载量,地理来源或旅行史无关.

结论:

艾滋病毒-2感染似乎不是获得HEV感染的重要风险因素.
在HIV-2感染者中,慢性HEV感染的发生率似乎没有增加.
进一步的研究可能是有必要的,以阐明HEV和HIV-2在不同流行病学背景下的特定相互作用.

关键词:

这是 HEV HEV.艾滋病毒-2 艾滋病毒-2 葡萄牙葡萄牙葡萄牙流行程度流行程度

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