对自闭症和自闭症特征中头部周长轨迹的纵向研究
Sarah A Ashley1, Kate Merritt2, Francesca Solmi2
1Division of Psychiatry, University College London, London, UK. sarah.ashley.20@ucl.ac.uk.
Journal of autism and developmental disorders
|October 12, 2024
概括
被诊断为自闭症谱系障碍 (ASD) 的儿童从出生到青春期头部周长更大. 相比之下,较高的自闭症特征与较小的头周长有关,表明不同的发育模式.
科学领域:
- 神经发育障碍 神经发育障碍
- 儿科生长研究的研究.
- 自闭症谱系障碍 (ASD) 研究研究
背景情况:
- 头周长是大脑发育和大小的关键指标.
- 以前的研究表明,自闭症谱系障碍 (ASD) 的头周长增加,但其发展轨迹和整个谱系的表现尚未完全理解.
- 了解自闭症患者的头周长图案,可以提供对早期大脑发育的见解.
研究的目的:
- 与对照组相比,研究自闭症儿童从出生到15岁的头周长轨迹.
- 检查ASD的头周长差异是否在整个童年和青春期持续存在.
- 探索自闭症特征较高的儿童和患有自闭症和并发性认知学习需求 (CLN) 的儿童的头部周长模式.
主要方法:
- 利用了来自阿文长度研究的父母和儿童 (ALSPAC) 的数据.
- 与对照组 (N=6,404和N=6,230分别) 相比,与ASD诊断的儿童 (N=78) 和高自闭症特征 (N=639) 的头周长轨迹进行了比较.
- 进行了ASD与共患性认知学习需求 (CLN) 的探索性分析.
主要成果:
- 与对照组相比,被诊断患有自闭症的儿童从出生到青春期的头周长较大 (p<0.05).
- 这些差异在患有ASD和并发性CLN的儿童中更为明显.
- 相反,自闭症特征较高的儿童的头周长明显小于对照组.
- 身高作为共同变量显示,对群体差异的证据很弱.
结论:
- 患有自闭症儿童的头周长轨迹与对照儿童的轨迹不同,并持续到青春期.
- 在临床自闭症病例和非临床自闭症特征的个体之间观察到不同的头周长增长模式.
- 研究结果表明,不同的神经发育路径可能是临床ASD与下值自闭症特征的基础.
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