在患有帕金森病的患者中,高密度表面电动图对上腺肌肉的评估
Masahiro Nakamori1, Kohei Yoshikawa2, Megumi Toko1
1Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Journal of the neurological sciences
|October 12, 2024
概括
高密度表面电肌图 (HD-sEMG) 在帕金森病 (PD) 患者中显示出明显的状腺肌肉变化. 宫电刺激改善了肌肉活动,这表明HD-sEMG可以监测PD相关的吞条件和治疗有效性.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 康复医学 康复医学 康复医学
背景情况:
- 帕金森病 (PD) 由于运动单元功能障碍,通常会影响吞.
- 高密度表面电肌图 (HD-sEMG) 提供了一种非侵入性方法来分析运动单元 (MU) 活动.
- 甲状腺上部肌肉对于吞至关重要,并且可以受到PD的影响.
研究的目的:
- 为了研究使用HD-sEMG的PD患者的Suprahyoid肌肉中的MU招募和行动潜力特征.
- 为了评估这些肌肉特征在宫穿皮干扰电流刺激后发生的变化.
- 在PD患者和健康对照者之间比较HD-sEMG的发现.
主要方法:
- 在PD患者和健康对照中,HD-sEMG记录了PD患者和健康对照中舌头升高期间的状腺上部肌肉电活动.
- 分析包括在最大自愿收缩 (MVC) 期间修改的,变化系数,相关系数和根平均平方 (RMS).
- 患有PD的患者 (Hoehn-Yahr阶段2-4) 接受了为期8周的宫外皮干扰电流刺激,并进行了干预前后的HD-sEMG评估.
主要成果:
- 与健康对照组相比,患有PD的患者在60%的MVC下显著减少了RMS (p=0.007).
- 在刺激后,40%和60%的MVC的相关系数显著下降 (p=0.040,p=0.048).
- 宫刺激导致RMS在60%的MVC (p=0.035) 显著增加.
结论:
- 在PD患者中,HD-sEMG确定了特征性的状腺肌肉活动模式.
- 该技术有效地检测到由电刺激引起的微妙神经肌肉变化.
- HD-sEMG显示出其作为评估吞相关肌肉状况和PD治疗干预措施的有价值工具的潜力.
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