硫化素纳米颗粒用于库尔库明输送:稳定性,体外释放和结合机制
Bao Zhang1, Shen Long1, Ran Feng1
1Engineering Research Center of Bio-process, Ministry of Education, Hefei University of Technology, 193 Tunxi Road, Hefei, Anhui 230009, PR China; School of Food and Biological Engineering, Hefei University of Technology, 193 Tunxi Road, Hefei, Anhui 230009, PR China.
Food chemistry
|October 12, 2024
概括
新型二氧化乳纳米颗粒有效封装黄素,提供有针对性的肠道输送. 这些二硫化物交叉连接的纳米颗粒显示出增强的酶抵抗性和水化合物输送的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 黄素是一种疏水化合物,在有效的装载和输送方面面临着挑战.
- 开发新的纳米载体对于提高疏水药物的生物可用性至关重要.
- 改性德克斯为纳米粒子开发提供了一个多功能平台.
研究的目的:
- 开发新的二硫化物交联纳米颗粒,使用修改后的德克斯进行黄素封装.
- 研究这些纳米粒子的特性和体外释放特征.
- 评估这些纳米颗粒在水化合物的向输送方面的潜力.
主要方法:
- 通过氧化和移植合成硫酸脱素 (Dt-SH).
- 在水溶液中纳米粒子自组装.
- 纳米粒子大小,泽塔潜力,形态和酶耐药性的表征.
- 在体外肠道向释放研究中,使用黄素作为模型.
- 使用光谱学和热力学分析进行约束相互作用分析.
主要成果:
- 硫化素纳米颗粒表现出增强的酶抵抗性和无形的,状的形态.
- 球形纳米粒子 (92.52157.12nm) 形成了正泽塔电位 (+23.59到+29.90mV).
- 醇修饰促进了纳米粒子的相互连接和聚合.
- 纳米颗粒显示了依赖pH值的尺寸变化,并且在实验室中证明了肠道曲素的向释放.
- 黄素的结合主要是由结,范德瓦尔斯力和疏水性相互作用介导的.
结论:
- 新型硫化德克斯特林纳米颗粒是黄素的有效载体.
- 这些纳米粒子显示出向向肠道输送疏水化合物的潜力.
- 开发的纳米载体系统提供了增强的酶耐药性和受控释放特性.
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