人类指数作为补充预测指标和2型糖尿病发病率之间的关联; Panasonic 队列研究 21
Genki Kobayashi1, Tomohiro Shinozaki2, Hiroshi Okada1
1Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Diabetes research and clinical practice
|October 12, 2024
概括
腰与身高的比率 (WHtR) 有效地预测了日本男性的2型糖尿病. 对于女性来说,WHtR和腰部校正的BMI (wBMI) 都是有效的预测指标,优于腰围 (WC).
科学领域:
- 代谢性疾病研究研究.
- 人类测量和公共卫生.
- 糖尿病流行病学 糖尿病流行病学
背景情况:
- 2型糖尿病 (T2D) 是一个日益严重的全球健康问题.
- 准确预测T2D风险对于有针对性的干预至关重要.
- 传统的人类指数在不同的人口中可能具有不同的预测能力.
研究的目的:
- 为了比较日本人口中T2D发病率的五个人类指数的预测能力.
- 为这些指数在日本男性和女性中建立实际的切断值.
- 在这个人口群体中确定T2D风险评估最有效的指数.
主要方法:
- 分析了155,623名日本参与者的大量队列.
- 数据跨越2008年至2021年,包括医疗检查.
- 使用时间依赖的接收器运行特征 (ROC) 曲线分析来评估13年的预测能力.
主要成果:
- 腰与身高的比率 (WHtR) 在男性中显示出高预测能力 (AUC=0.717).
- 在女性中,腰部校正的BMI (wBMI) 和WHtR显示出高预测能力 (AUC分别为0.829和0.826).
- WHtR对男性最有效;WHtR和wBMI优于腰围 (WC),与女性的BMI相比.
结论:
- WHtR是日本男性T2D的优越预测剂.
- WHtR和wBMI是日本女性的有效预测指标,表现优于WC.
- 这些发现支持使用WHtR和wBMI进行日本人口T2D风险评估.
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