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Updated: May 12, 2026

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在药片涂层过程中,通过表面增强的拉曼散射在药片中应用隐形纳米信标以确保可追溯性

Toshiya Yasunaga¹, Takao Fukuoka², Akinobu Yamaguchi³

¹Laboratory of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya, 464-8650 Japan.

International journal of pharmaceutics

|October 12, 2024

概括

这项研究将隐形纳米信标 (NB) 集成到制药片的涂层中,以检测假冒. 该技术提供了快速的剂量认证和实时涂层厚度监测.

科学领域:

制药科学制药科学
分析化学分析化学
材料科学材料科学材料科学

背景情况:

剂量认证对于防伪和药品可追溯性至关重要.
隐形纳米信标 (NB),利用合金纳米粒子和记者分子,表现出表面增强的拉曼散射 (SERS) 验证.
将微标签技术集成到现有的制药制造工艺中需要进一步研究.

研究的目的:

用传统方法证明隐形纳米信标 (NB) 在平板电脑涂层中被纳入.
通过SERS评估NB涂层药片在假冒检测方面的有效性.
探索NB作为实时追踪器用于涂层厚度监测的潜力.

主要方法:

通过简单的混合方法与标准涂层溶液将NB纳入平板涂层.
用785nm激光激发用于SERS检测的NB涂层片的分析.
评估SERS强度与涂层时间的关系.
使用色度分析对NB涂层药片的评估.

主要成果:

从NB涂层片中获得了快速和明显的SERS反应,证实了有效的假冒检测.
NB的SERS强度与涂层时间正相关,从而可以实时监测涂层厚度.
涂有NB的药片在视觉和颜色测量上无法与无NB的药片区分开来,这表明它们具有隐形性质.

结论:

隐形纳米信标可以有效地集成到使用常规制造技术的药品平板电脑涂层.
开发的NB技术提供了一种先进而高效的剂量假冒检测方法.
NB作为一个有价值的追踪器,用于实时监控制药涂层过程.

关键词:

打击假冒和伪造的行为金纳米颗粒的金子.一个微型虫.在表面增强的拉曼散射中.平板电脑上的涂层.可追溯性可追溯性

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