相关实验视频

Updated: Jun 10, 2025

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

甲基普雷尼索隆用于急性A型大动脉剖析患者进行全弓置换:奖牌试验的设计和理由

Shujie Yan¹, Fuqing Jiang², Yanhua Sun³

¹Department of Cardiopulmonary Bypass, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Cardiovascular Diseases, Beijing, China.

American heart journal

|October 12, 2024

概括

本试验旨在调查甲基普雷迪尼索隆是否能在急性A型大动脉剖析中进行大动脉门置换后减少主要器官损伤. 结果尚未公布,但旨在澄清这种高风险手术的治疗有效性.

科学领域:

心血管外科心血管外科
麻醉学麻醉学
关键护理医学关键护理医学

背景情况:

针对急性A型大动脉解剖 (ATAAD) 的紧急全大动脉门置换 (TAAR) 携带高死亡率和发病率,部分原因是系统性炎症.
一种抗炎药物甲基普雷迪尼索隆 (methylprednisolone) 可能会减轻这种反应,但其在ATAAD治疗TAAR中的有效性尚不清楚.
目前的临床实践表明,在全球范围内,甲基前尼索隆的使用和剂量存在差异.

研究的目的:

为了评估甲基普雷迪尼索隆在减少术后主要器官损伤的有效性,在接受TAAR治疗ATAAD的患者中.
评估甲基普雷迪尼索隆对关键不良结果的影响,包括死亡率,神经缺陷,急性损伤和呼吸道并发症.

主要方法:

奖牌试验是一个前性的,多中心的,随机的,双盲的,安慰剂控制的研究.
340名接受TAAR的ATAAD成年患者将被随机分配1:1接受500毫克甲基前尼索隆或安慰剂,然后在心肺旁路术前接受治疗.
主要结局是所有原因死亡,神经缺陷,KDIGO II-III急性损伤或呼吸系统综合征的复合体,在术后30天.

主要成果:

该研究正在进行中,截至2024年9月5日,在340名受试者中,有323名受试者参加了该研究.
数据收集和分析正在等待;结果将在完成后公布.
该试验旨在提供关于甲基前尼索隆在该患者群体中的益处的明确证据.

结论:

梅达尔试验旨在确定500毫克甲基普雷迪尼索隆剂量的有效性,以改善TAAR接受TAAD患者的治疗结果.
研究结果将为临床指导方针提供有关在高风险大动脉手术中使用抗炎药物的信息.

更多相关视频

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

相关概念视频

Aneurysm IV: Nursing Management

Aneurysm IV: Nursing Management

Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...

Aneurysm III: Interprofessional Care

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...

Aortic Regurgitation I: Introduction

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...