相关实验视频

Updated: Jun 10, 2025

Induction and Validation of Cellular Senescence in Primary Human Cells

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

在单细胞水平上研究人类衰老

Yunjin Li¹, Qixia Wang², Yuan Xuan³

¹Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200443, China.

Ageing research reviews

|October 12, 2024

概括

单细胞测序 (SCS) 揭示了人类衰老的细胞细节. 本综述涵盖了SCS应用,多组学和先进方法,以了解衰老机制和疾病.

科学领域:

老年学是一门学科.
分子生物学分子生物学
基因组学就是基因组学.

背景情况:

人类的衰老涉及生理衰退和疾病风险增加.
人们对衰老机制的理解尚不完全.
单细胞测序 (SCS) 提供了对细胞衰老的高分辨率见解.

研究的目的:

审查SCS技术在人类衰老研究中的应用.
讨论老龄化研究中的多主题和先进方法.
要突出对衰老研究的资源.

主要方法:

审查单细胞基因组学,转录基因组学,表观基因组学和蛋白质基因组学.
在单个单元中讨论多omics集成.
将SCS与空间转录学和质谱学的整合.

主要成果:

SCS可以识别衰老的生物标志物和细胞亚群.
阐明与衰老相关的信号通路和组织特征.
研究与衰老相关的疾病,并确定新的治疗点.

结论:

在剖析人类衰老方面,SCS技术是关键的.
多学科和先进的方法提高了对衰老过程的理解.
与衰老相关的数据库是未来研究的宝贵资源.

关键词:

与衰老相关的疾病.生物标志物生物标志物人类的衰老人类的衰老单细胞多组体的单细胞多组体.单细胞测序是一种单细胞测序.

更多相关视频

Using Microfluidic Devices to Measure Lifespan and Cellular Phenotypes in Single Budding Yeast Cells

Using Microfluidic Devices to Measure Lifespan and Cellular Phenotypes in Single Budding Yeast Cells

Published on: March 30, 2017

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

相关概念视频

Mitochondria

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...