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在静态压力期间解开自主心血管控制复杂性:来自数学模型的见解

Martin Miranda Hurtado¹, Rafael Kaempfer², Justen R Geddes³

¹Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Catolica de Chile, Avda.Vicuña Mackenna 4860, Macul, Santiago, 8970117, Chile; Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive, Calgary, T2N 4N1, Canada; School of Nursing, Pontificia Universidad Catolica de Chile, Avda.Vicuña Mackenna 4860, Macul, Santiago, 8970117, Chile.

Mathematical biosciences

|October 12, 2024

概括

这项研究模拟了自主神经系统的模型.

科学领域:

心血管生理学心血管生理学
计算生物学计算生物学
自主神经科学自主神经科学

背景情况:

自主系统对心血管的控制是复杂的.
静态不耐症综合征缺乏明确的病理生理学理解.
现有的模型不能完全捕捉同情的控制动态.

研究的目的:

开发一个对同情心血管控制的数学模型.
模拟健康个体和患有静止不耐症的人的反应.
为了确定自主功能障碍的潜在生物标志物.

主要方法:

制定了一个分区普通微分方程模型.
在头向上倾斜测试 (HUTT) 期间使用了非侵入性心电图和血压监测.
敏感性分析,参数选择和优化估计的患者特定参数.

主要成果:

该模型成功地复制了对HUTT的各种血压反应.
七个敏感和可识别的参数被确定为潜在的生物标志物.
该模型的控制器模拟了同情神经系统的操作.

结论:

计算建模可以有效地评估自主神经系统障碍.
识别的参数显示了患者分类和生物标志物开发的潜力.
对自主功能障碍的计算方法的进一步研究是有必要的.

关键词:

自主神经系统的自主神经系统.数学模型是一个数学模型.正静性高血压是指正静性高血压.正静性低血压是正静性的.血管综合症血管综合症

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